Endocrine Abstracts

Endocrinopathies are one of the most common side effects induced by immunotherapy. The side effects result from the activation of immune system, which affects not only cancerous but also healthy body cells. In most cases, only one endocrinopathy occurs, but in our presented case we describe multiple endocrinopathies that occurred to a one person. 53-years-old male patient was referred to the Emergency department due to severe hyperglycemia (37.13 mmol/l) and the following symp...

Objective: To assess olfactory bulbs sizes and define the most common molecular defects in adolescents with congenital isolated hypogonadotropic hypogonadism.Materials and Methods: Single-centre comparative study. 36 patients were included. The main group consisted of 21 patients with mean age of 15.9 years (17 boys, 4 girls) with congenital isolated hypogonadotropic hypogonadism (IHH): 13 - with Kallmann syndrome (KS), 8 – with normosmic isolated h...

Introduction: Follicular thyroid carcinoma (FTC) is the second most common malignancy of the thyroid gland. Distant metastasis, usually in bones or lungs, can be found in about 10%–15% of cases. A clinical case of FTC distant bone metastasis is presented.Case: A 62-year-old male came to endocrinologist for annual follow-up (FU) of multinodular goiter, euthyreosis in 2010. Two years before prostate carcinoma (T1N0M0) was also diagnosed for the patien...

Introduction: GH producing pituitary adenomas are associated with infertility. Hereby the first case in Lithuania, when acromegaly patient got pregnant and delivered is reported.Case presentation: 33-year-old woman visited endocrinologist complaining of secondary amenorrhoea. Due to elevated prolactin – 3016 mU/l (NR<418), bromcriptine treatment was started. The patient discontinued treatment after three months because of restoration of regular ...

Introduction: Management of patientswith congenital adrenal hyperplasia (CAH) is a challenge to find a right balance of glucocorticoid doses and long-term consequences of overtreatment isassociated with increased risk of cardiometabolic disorders.The aim of our study was to evaluate body mass index (BMI), body composition, blood pressure (BP) and insulin sensitivity in children and youth with CAH in comparison with healthy control subjects.<p class="...

Hypoparathyroidism is a rare disorder characterised by hypocalcaemia and hyperphosphataemia in the presence of low or inappropriately normal parathyroid hormone levels. Currently there are limited data on the burden of illness and healthcare resource utilisation (HCRU) associated with chronic hypoparathyroidism in Canada. A retrospective cohort analysis with matched controls was conducted to examine HCRU in patients with chronic hypoparathyroidism in Ontario, Canada. Data were...

Background: Depressive symptoms (DS) and diabetes-related distress (DD) are common comorbidities in diabetic patients adversely affecting diabetes self-management and patients’ well-being.Aim: To examine associations between DS and DD with glycaemic control, quality of life and diabetes self-management.Materials and methods: Depressive symptoms, DD, quality of life, diabetes self-management and metabolic indicators were asses...

Case history: A 67-year-old lady was referred to an endocrinologist for autoimmune hypothyroidism diagnosed in 2004. A treatment combination of levothyroxine and liothyronine was used. She had a history of recurrent metastatic ER-positive HER-2 negative lobular breast cancer with liver and bony metastatic involvement. She commenced with Letrozole (aromatase inhibitor) and Palbociclib (CDK inhibitor), later Fulvestrant (antioestrogen) and Crizotinib (tyrosine kinase inhibitor)....

As thyroid hormones (TH) are essential for the normal heart function, a low TH state in ischemic cardiovascular events is often correlated to a poor prognosis. While clinical and experimental data suggests that TH intervention in acute myocardial infarction might be beneficial, a detailed insight in the mechanisms on TH action in IR injury or post infarct recovery of the heart is still lacking. In this study, we examined the effect of thyroid hormone pre- and postconditioning ...

Background: Data on the effects of long term glucocorticoid (GC) treatment on bone mineral density (BMD) in patients with congenital adrenal hyperplasia (CAH) are controversial. Objectives: To evaluate BMD and vitamin D status in adolescents and young adults with CAH in comparison with healthy controls.Methods: 32 patients with classical CAH (13 males; mean of age 26.0±7.1 years (14.0–37.3) were compared to 32 healthy con...